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PureBiotic™ 60 vcaps


Purchase options
$52.75
$50.11

Purchase options
$52.75
$50.11


Purchase options
$52.75
$50.11

Purchase options
$52.75
$50.11


  • We are very pleased to inform you we have produced a truly superior PureBiotic™ formula:

    MORE POTENT · LESS CAPSULES · MORE EFFECTIVE SPECIES · OPTIMIZE IMMUNITY · MORE REGENERATIVE IMPACT · SAME PRICE!

    Natural Full Spectrum Probiotic Blend Featuring 15 Probiotic Species Blended to Attain +28 Billion CFU per Serving

    Probiotics help calm and balance healthy immune functions.81,82 Yet in other appropriate situations, probiotics may promote activation of healthy first tier immune cells (macrophages).83 In essence, probiotics support superior immunoregulation important for well-rounded immune performance.84

    Our new advanced PureBiotic™ formula optimally promotes superior immune system functions while facilitating better digestive functions than ever before. It remains the ideal choice for individuals with poor B-vitamin status, or for those production who recently have undergone antibiotic therapy. Our new formula maximally supports healthy gut microbe growth and prevalance plus excellent bowel elimination.*

    Our New Specific Formula Advantages Now Includes 5  different Bifidobacterium:

    In general, Bifidobacteria are among the best colonizers of the human gut, especially with continued supplementation.1,2 For perspective, Bifidobacteria are considered by some scholars to be more important to human gut health than contributions made by the Lactobacillus group.3 In breast-feeding infants, nearly 100% of probiotics colonizing the gut are Bifidobacteria, and climb to between 1010 to 1011 CFU/gram of the breast-fed infants’ feces.4 Several of their pan-functions are to digest carbohydrates, manufacture B-complex vitamins, support a healthy gut microbiome and promote a mature immune system.5 By adulthood, Bifidobacteria will comprise only 5% to 10% of the total gut microbiota.*6

    Among the more prevalent Bifidobacterium residing in the human gut, from infancy into adulthood, are:*

    • Bifidobacterium bifidum,

    • B. breve,

    • B. longum,

    • B. animalis lactis and

    • B. lactis.

     

    1. Bifidobacterium bifidum – This specie has been extensively studied and has excellent ability to colonize the gut. Studies show it was among the top in persisting in the feces after over 3 weeks from when supplementation had ceased.*7

     2. B. breve - is also known to be immediately taken up and colonize the gut of new born infants.*8

     3. B. longum – As mentioned above, studies reveal that B. longum is one specie that is persistent in the gut into adulthood. It is considered to be the most prevalent in the human gut of all the Bifidobacteria.9 The specie possesses remarkable immune modulating effects throughout the life of the host. B. longum has good ability to colonize in the gut after supplementation has ceased.*10

     4. B. animalis lactis (VK2) – A study in combinations of select probiotics have shown that B. animalis lactis, when combined with L. acidophilus, promotes healthy gut microbe growth.*11

     5. B. lactis (BI-04) – This bacteria has an unusually high tolerance exposures to both high concentrations of oxygen and acid, leaving it very desirable to ferment milk products. B. lactis is most prevalent in human infants.*12

    Into adulthood, Bifidobacteria continue to promote a long list of health benefits, but decline in overall numbers by at least one order of magnitude. On the other hand, Lactobacillus colonization escalates and will attain approximately 107 CFU/gram of feces.13 Both genus do not promote any kind of deleterious effects on the human being.*

    However, both Bifidobacteria and Lactobacillus are greatly outnumbered by a variety of other not-so-friendly (opportunistic or pathogenic) gut microbes by approximately 8 to 1. Overall the gut will contain from 100 to 400 Trillion microbes, or about 10X to 40X the number of total human cells in the body. So, the main job of both Bifidobacteria and Lactobacillus is to help reign-in rogue microbial actions which might otherwise turn against regions of human tissues.*

    Our New PureBiotic™ formula has 8 of the more studied Lactobacillus spp. Among the more common of Lactobacilli found in the human gut when consuming healthy diets are:*

    • Lactobacillus acidophilus

    • L. helveticus

    • L. plantarum

    • L. lactis

    • L. rhamnosus

    • L. salivarius

    • L. casei

    • L. bulgaricus

    • L. brevis

     

    6. Lactobacillus acidophilus (LA-14) – has the ability to temporarily populate deeply into the human gut. Interestingly, when it does so, the numbers of Lactobacilli in the gut soar after only 7 days of supplementation, but returns to their prior levels after 9 days after L. acidophilus supplementation is stopped. Therefore, this implies that to keep the numbers of lactobacilli up to optimal, L. acidophilus should be taken regularly with other lactobacilli.*14

     7. L. helveticus – the specie is renown for impacting the immune system in a multifunctional capacity in that both a variety of healthy bacteriocins as well as a fleet of bioactive peptides are secreted in abundance. In general, L. helveticus colonizes the human gut adequately to perform a plethora of health benefits.*15

     8. L. plantarum (LP-115) – is a specie well known to be able to pass through the upper intestinal tract to freely colonize the human gut. Several researchers have pointed out the L. plantarum acts similar to a living vaccine, providing ongoing immune modulation when and as needed.*16

    9. L. rhamnosus (LR-32) – is an excellent species to promote healthy modulation in hyperimmune state. For example, L. rhamnosus is known to promote balance to healthy T-cell immune states. More specifically, L. rhamnosus modulates the pre-cursor dentritic cells (DCs), which in turn supports healthy T-cell populations and functions.*17

    10. L. salivarius (LS-33) – this species is among the most populated in the human oral cavity. It protects dental integrity and promotes healthy oral immunity.*18

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    REFERENCES

    AThe gut microbiota refers to every resident microorganism, both microbes and macrobes, living in a host.

    1. Roger LC, et al. Examination of faecal Bifidobacterium populations in breast- and formula-fed infants during the first 18 months of life. Microbiology. 2010;156:3329–3341.Abstract/FREE Full Text
    2.  Favier CF, et al. Molecular monitoring of succession of bacterial communities in human neonates. Appl Environ Microbiol. 2002;68:219–226. Abstract/FREE Full Text
    3.  Mitsuoka, T. Bifidobacteria and their role in human health. Journal of Industrial Microbiology. 1990;6:263. https://doi.org/10.1007/BF01575871.
    4.  Gill H, Prasad J. Probiotics, Immunomodulation, and Health Benefits. In: Bösze Z. (eds) Bioactive Components of Milk. Advances in Experimental Medicine and Biology. 2008;606. Springer, New York, NY.
    5.  Macfarlane GT, Cummings JH. Probiotics and prebiotics: can regulating the activities of intestinal bacteria benefit health? BMJ. 1999;318:999.
    6.  Gill H, Prasad J. Probiotics, Immunomodulation, and Health Benefits. In: Bösze Z. (eds) Bioactive Components of Milk. Advances in Experimental Medicine and Biology. 2008;606. Springer, New York, NY.
    7.  Bartosch S, et al. Microbiological Effects of Consuming a Synbiotic Containing Bifidobacterium bifidum, Bifidobacterium lactis, and Oligofructose in Elderly Persons, Determined by Real-Time Polymerase Chain Reaction and Counting of Viable Bacteria (see Table 2). Clinical Infectious Diseases. 2005 Jan; 40(1):28–37. See: https://doi.org/10.1086/426027
    8. Bottacini F, et al. Comparative genomics of the Bifidobacterium breve taxon. BMC Genomics. 2014;15:170.
    9.  Chaplin AV, et al. Intraspecies Genomic Diversity and Long-Term Persistence of Bifidobacterium longum. PLoS One. 2015; 10(8): e0135658.
    10. Bartosch S, et al. Microbiological Effects of Consuming a Synbiotic Containing Bifidobacterium bifidum, Bifidobacterium lactis, and Oligofructose in Elderly Persons, Determined by Real-Time Polymerase Chain Reaction and Counting of Viable Bacteria (see Table 2). Clinical Infectious Diseases. 2005 Jan; 40(1):28–37. See: https://doi.org/10.1086/426027
    11. McFarland LV, et al. United European Gastroenterol J. 2016 Aug; 4(4): 546–561.
    12. Meile L, Ludwig W, Rueger U, Gut C, Kaufmann P, Dasen G, Wenger S, Teuber M. Bifidobacterium lactis sp. nov., a moderately oxygen tolerant species isolated from fermented milk. Syst Appl Microbiol. 1997;20:57–64.
    13.  Gill H, Prasad J. Probiotics, Immunomodulation, and Health Benefits. In: Bösze Z. (eds) Bioactive Components of Milk. Advances in Experimental Medicine and Biology. 2008;606. Springer, New York, NY.
    14.  Lidbeck A, et al. Impact of Lactobacillus acidophilus Supplements on the Human Oropharyngeal and Intestinal Microflora. Scandanavian Journal of Infectious Diseases. 1987;19(5):531-7.
    15.  Skrzypczak K, Gustaw W, Waśko A. Health-promoting  properties  exhibited  by Lactobacillus helveticus strains. ACTA ABP Biochimica Polonica. 2015;62(4): 713-20.
    16.  de Vries MC, Vaughan EE, Kleerebezem M, de Vos WM. Lactobacillus plantarum—survival, functional and potential probiotic properties in the human intestinal tract. International Dairy Journal. 2006 Sep;16(9):1018-28.
    17. Braat H, et al. Lactobacillus rhamnosus induces peripheral hyporesponsiveness in stimulated CD4+ T cells via modulation of dendritic cell function. The American Journal of Clinical Nutrition. 2004 Dec;80(6):1618–1625. See: https://doi.org/10.1093/ajcn/80.6.1618
    18. Koll P, Mandar R, Marcotte H, Leibur E, Mikelsaar M, Hammarstrom L. Characterization of oral lactobacilli as potential probiotics for oral health. Oral Microbiol Immunol 2008:23:139–147.
    19.  Chapat L, Chemin K, Dubois B, Kaiserlian D. Lactobacillus casei reduces CD8+ T cell‐mediated skin inflammation. European Journal of Immunology. 2004 Sep;34(9):2520-28.
    20.  Hou J-c, et al. Effect of culturing conditions on the expression of key enzymes in the proteolytic system of Lactobacillus bulgaricus. J Zhejiang Univ Sci B. 2015 Apr; 16(4): 317–326.
    21. Azizi F, Najafi MBH, Dovom MRE. The biodiversity of Lactobacillus spp. from Iranian raw milk Motal cheese and antibacterial evaluation based on bacteriocin-encoding genes. AMB Express. 2017; 7: 176.
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    24. Molina-Gutierrez A, et al. In Situ Determination of the Intracellular pH of Lactococcus lactis and Lactobacillus plantarum during Pressure Treatment. Appl Environ Microbiol. 2002 Sep; 68(9): 4399–406. 
    25.  See - The Regeneration Effect: A Professional Treatise on Self-Healing by Dr. John Apsley è https://www.amazon.com/Regeneration-Effect-Professional-Treatise-Healing/dp/B0029ZN6LY/ref=sr_1_5?keywords=John+Apsley&qid=1553438206&s=hpc&sr=8-5
    26.  Griffiths MW, Tellez AM. Lactobacillus helveticus: The Proteolytic System. Front Microbiol. 2013;4:30.
    27.  Wu Q, Tun HM, Law Y-S, Khafipour E, Shah NP. Common Distribution of gad Operon in Lactobacillus brevis and its GadA Contributes to Efficient GABA Synthesis Toward Cytosolic Near-Neutral pH. Front Microbiol. 2017;8:206.
    28.  Centanni M, et al. Tumor Necrosis Factor Alpha Modulates the Dynamics of the Plasminogen-Mediated Early Interaction between Bifidobacterium animalis subsp. Lactis and Human Enterocytes. Appl Environ Microbiol. 2012 Apr;78(7):2465-9.
    29.  Riveiere A, Selak M, Lantin D, Leroy F, Vuyst LD. Bifidobacteria and Butyrate-Producing Colon Bacteria: Importance and Strategies for Their Stimulation in the Human Gut.; Front Microbiol. 2
    30.  Liu H-X, Keane R, Sheng L, Wan Y-JY. Implications of Microbiota and Bile Acid in Liver Injury and Regeneration. J Hepatol. 2015 Dec;63(6):1502-10.
    31.  He X, Slupsky CM, Dekker JW, Haggarty NW, Lönnerdal B. Integrated Role of Bifidobacterium animalis subsp. lactis Supplementation in Gut Microbiota, Immunity, and Metabolism of Infant Rhesus Monkeys. mSystems. 2016 Nov-Dec; 1(6): e00128-16.
    32.  Gasbarrini G, Bonvicini F, Gramenzi A. Probiotics History. J Clin Gastroenterol. 2016 Nov/Dec;50 Suppl 2, Proceedings from the 8th Probiotics, Prebiotics & New Foods for Microbiota and Human Health meeting held in Rome, Italy on September 13-15, 2015:S116-S119.
    33.  Clemente JC, Ursell LK, Parfrey LW, Knight R. The impact of the gut microbiota on human health: an integrative view. Cell. 2012;148(6):1258–1270. doi: 10.1016/j.cell.2012.01.035.[PMC free article]
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    37. Cani PD, Neyrinck AM, Fava F et al. Selective increases of bifidobacteria in gut microflora improve high-fat-diet-induced diabetes in mice through a mechanism associated with endotoxaemia. Diabetologia 2007; 50: 2374–2383. 
    38.  Liévin-Le Moal V, Servin AL. Clin Microbiol Rev. 2014 Apr; 27(2): 167–199. 
    39.  Rocha-Ramírez LM, et al. Probiotic Lactobacillus Strains Stimulate the Inflammatory Response and Activate Human Macrophages. J Immunol Res. 2017; 2017: 4607491. 
    40.  Plaza-Diaz JGomez-Llorente CFontana LGil A. Modulation of immunity and inflammatory gene expression in the gut, in inflammatory diseases of the gut and in the liver by probiotics. World J Gastroenterol. 2014 Nov 14;20(42):15632-49.
    41.  Ayabe T, Satchell DP, Wilson CL, Parks WC, Selsted ME, Ouellette AJ. Secretion of microbicidal alpha-defensins by intestinal Paneth cells in response to bacteria. Nat Immunol. 2000 Aug; 1(2):113-8.
    42.  Stappenbeck TS, Hooper LV, Gordon JI. Developmental regulation of intestinal angiogenesis by indigenous microbes via Paneth cells. Proc Natl Acad Sci U S A. 2002 Nov 26; 99(24):15451-5.
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    46.  See – Integrative Regenerative Medicine: Colloidal Regenerative Factors (cRFs) and The Regeneration Effect è  https://www.amazon.com/Integrative-Regenerative-Medicine-Colloidal-Regeneration-ebook/dp/B01EEPYJRQ/ref=sr_1_1?keywords=John+Apsley&qid=1553438206&s=hpc&sr=8-1
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    48.  Patel R, DuPont HL. New Approaches for Bacteriotherapy: Prebiotics, New-Generation Probiotics, and Synbiotics. Clin Infect Dis. 2015 May 15;60(Suppl 2):S108-S121.
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    83. Rocha-Ramírez LM, et al. Probiotic Lactobacillus Strains Stimulate the Inflammatory Response and Activate Human Macrophages. J Immunol Res. 2017; 2017: 4607491.
    84. Yousefi B, et al. Probiotics Importance and Their Immunomodulatory Properties. J Cell Physiol. 2019 Jun;234(6):8008-18.